Can you compromise the addition of noise in the image?
Will the noise be visible if the shot is at a high ISO?
The answer to most of the concerns is, it depends on what the final intent of your photo is. For instance, if you are shooting with a Nikon D5 at a relatively high ISO (>10,000) and you intent to print the images on a 8x12 photo paper, due to the sheer number of pixels and the compression that will occur by packing all the pixels into a 8x12 size, the noise on the print will practically be invisible. On the other hand, if your intent is to print the same image the size of a bill board and want to avoid noise, you will be better off shooting at low ISO.
Most of the time people look at the images on the screens of a computer and zoom to 1:1 and say that the image has a lot of noise. You must note that when zooming in at 1:1 even if you shoot at a relatively low ISO you will see some noise. The only purpose that I have found for a 1:1 is for critical review of the image.